Rosie O'Donnell Calls Weight Loss Drug Mounjaro A 'Life Saver' As She Celebrates Being A Size 12
By Favour Adegoke on August 13, 2025 at 5:45 PM EDT
Rosie O'Donnell has revealed that she’s now a size 12 thanks to Mounjaro, healthier eating, and lifestyle changes like cutting out Diet Coke.
The famous comedian shed 50 pounds and embraced cooking for herself in Ireland, sometimes experimenting with trends like TikTok’s “Tiffany plate.”
Rosie O’Donnell's latest milestone comes after she slammed President Donald Trump’s threat to revoke her U.S. citizenship.
Rosie O’Donnell Admits She's 'Shocked' That She's 'A 12'
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Rosie O'Donnell, 63, recently shared an exciting update about her latest clothing size, and she admitted that she was surprised by the result.
The actress, talk show host, and comedian showed off her slimmer figure in a fitted outfit while revealing the news to her Instagram followers.
She wrote, "Ok, so went shopping to buy a comfy lounge wear outfit for my 22-hour flight to Australia. Was undecided as I can't see myself in this new smaller body.”
She added, "[My friends] took this photo of me in the dressing room — I am shocked I’m a 12 — #mounjaro is a lifesaver."
Fans Praise The Comedian For Her Weight Loss Milestone
Fans quickly flocked to O'Donnell's comment section to celebrate her weight loss transformation.
"Super impressive!!! You look wonderful," one wrote.
"Gosh, you look great! Wish I could get some Monjaro," another added.
A third shared: “Looking good!! And I feel this. I have lost 70 pounds over the last few years, and I still don't see it in the mirror.”
“You're feeling better, too, I’m sure! Look fabulous,” a fourth person noted about O'Donnell's weight loss.
Rosie O’Donnell Credits Mounjaro And Lifestyle Changes For Her 50-Pound Weight Loss
O'Donnell first revealed she was using Mounjaro in January 2023, sharing in a TikTok video that she had begun her weight loss journey. By this March, she gave an update, noting she had “lost more weight” after moving to Ireland.
"I am on Mounjaro for my diabetes, and one of the side effects is that you lose weight,” she explained. "But it’s also because I had a chef for over two years in Los Angeles, and I don't have a chef now. It's me cooking for Clay and me."
The “Now and Then” actress has credited the drug with helping her shed 50 pounds. Reflecting on her transformation, she said, “I can’t believe this is me now.”
She also shared that with her slimmer frame came a new wardrobe challenge.
“I'm one of those people who's always had a weight issue and now that I'm a size large, instead of an XL or a 2XL, I find it shocking,” O'Donnell stated. “I've been wearing elastic-waist pants for a very long time.”
The Comedian Shares Lifestyle Tweaks Behind Her Weight Loss, Tries TikTok’s ‘Tiffany Plate’ Trend
Alongside using Mounjaro, O'Donnell has embraced lifestyle changes to support her body transformation.
“I stopped drinking anything except water," she revealed in a January 2023 TikTok. “I really stopped drinking five or six Diet Cokes a day. All I drink is water now, and I'm not eating sugar as much as I can."
The “Tarzan” actress has also experimented with incorporating healthier meals.
In May, she tried TikTok’s popular “Tiffany plate” trend, a reimagined charcuterie board created by weight loss influencer Tiffany Magee.
“This is my first Tiffany platter,” she said in a video. “It’s on TikTok, and everyone makes their own little healthy food thing, and then they eat it during the day."
O'Donnell then explained that her platter includes "Babybel reduced-fat cheese," alongside eggs, sausage, olives, mushrooms, chicken breast, fruits, and vegetables.
Rosie O’Donnell Hits Back At Trump Over Citizenship Threat
Meanwhile, O’Donnell fired back at President Donald Trump last month following his threat to revoke her U.S. citizenship.
Taking to her Instagram hours after Trump’s comments, O’Donnell shared an image of the U.S. President alongside convicted sex offender Jeffrey Epstein, with whom Trump socialized decades ago amid ongoing calls for the full release of Epstein-related files.
Captioning the post, O’Donnell wrote: “I’m everything you fear. A loud woman, a queer woman, a mother who tells the truth, an American who got out of the country before you set it ablaze. You are everything that is wrong with America—and I’m everything you hate about what’s still right with it.”
She added a pointed jab at Trump, referencing HBO’s “Game of Thrones”: “You want to revoke my citizenship? Go ahead and try, King Joffrey, with a tangerine spray tan.”
