In a recent interview, Rob Lowe recounted his rollercoaster career journey over the past four decades.

The "Wayne's World" actor's most rewarding gig is firstly being a husband to Sheryl Berkoff since 1991.

Lowe's second most rewarding gig is being a father to his sons Matthew and John Owen.

Lowe overcame drug and alcohol addiction and is grateful for his professional and personal life balance.

The "Literally! With Rob Lowe" podcast host believes he knows the right questions to ask celebrities.

Lowe recalled his candid interview with Jennifer Aniston about the "Friends" reunion.

The actor believes he relates better to Aniston and other stars due to having similar experiences.

Lowe denied claims that Oprah's interview with Harry and Meghan Markle held at his Montecito city home.

The "9-1-1: Lone Star" actor believes the interview was held in Oprah's backyard.