Rob Lowe and Sheryl Berkoff got married in 1990.
Lowe said Berkoff was his partner for life.
The couple has two sons.
Lowe posted a picture of Berkoff earlier to celebrate her 61st birthday.
He said she was the most beautiful person he knew.
Before meeting Lowe a second time, Berkoff dated Keanu Reeves.
Berkoff helped Lowe while he tried to recover from substance abuse.
Berkoff’s job as a makeup artist allowed her to meet several celebrities.
Gwyneth Paltrow said Berkoff taught her how to perform oral sex when she was 15.
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