Cancer has been very cruel to John Travolta.

The award-winning actor has been put through the ringer when it comes to his loved ones losing their life to cancer.

Following the news of his on-screen love and real-life best friend Kirstie Alley’s death, The Blast did a deep dive into the women Travolta’s lost due to the disease.

Alley played Travolta’s on-screen wife in “Look Who’s Talking” (1989), “Look Who’s Talking Too”(1990), and “Look Who’s Talking Now” (1993).

She died from colon cancer that was “only recently discovered.”

This year, he also lost his “Grease” love interest, Olivia Newton-John.

She passed away from a 30-year battle with metastatic breast cancer.

In 2020 he lost his wife, Kelly Preston, to breast cancer.

She battled the disease for two years before her passing.