Ellen Pompeo appeared on "The Drew Barrymore Show" to discuss her exit from "Grey's Anatomy."

She said she wants to mix things up after staying on for nineteen years on the show.

Pompeo is open to trying new things and shares her plans for the new era.

She compared leaving the series to kids going away to college at 18.

The 53-year-old is focusing on her kids and will star in a Hulu series.

She shared the news of her leave on Instagram with a heartfelt message.

Fans were sad to see her go, as they expressed so under her post.

Pompeo almost did not take up the role of Meredith Grey in "Grey's Anatomy."

She revealed that she rarely watches the series during her free time.