"I am filled with immense gratitude for my journey on @thetalkcbs. It has been a wonderful experience and an honor to have been the moderator at The Talk."
Inaba replaced Julie Chen as a permanent co-host in 2019 but has been on a leave of absence from the show since April.
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I have decided to take a leave of absence from The Talk to focus on my well-being," she said at the time, "health is the most important thing.
Her announcement came shortly after Sharon Osbourne's comments caused a media firestorm that ended with an investigation and a hiatus.
Despite the drama, the host graciously wished the cast and crew well for the upcoming season.
"Life is good. And endings can be as beautiful as beginnings," she said.