November 14 is when the last episode of Grey's Anatomy featuring Justin Chambers as Alex Karev aired. The series has featured Justin Chambers for sixteen long years, and it's a terrible shock to fans everywhere to hear that he's leaving. After all, Alex and Meredith are the only original interns left on the show.
The original set of interns were: Meredith, George, Cristina, Alex and Izzie. Over the years it's slowly dwindled down until it was just Meredith and Alex... Now I guess it's just Meredith.