They've made the decision to step back as 'senior royals,' and forge their own path, becoming "financially independent" and carving out a "progressive" role for themselves in the world; what any of that means in detail we will have to wait and see.
However, Prince Harry and Meghan Markle's decision to basically quit their jobs as part of the royal family will see repercussions for the couple far and wide. It's not exactly the same as giving your two weeks notice at a normal job.
The whole thing is fraught with family drama and emotionally charged. For Harry, he is not just quitting a job but will be separating from his family unit, including his brother Prince William whom he was once so close to.